Luxury Hotels in Greenville

We've selected 18 of the Best Luxury hotels in Greenville for your 2026 vacation!

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High end Hotels in Greenville

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9.4
Excellent
234 Reviews

From

287$/night

Grand Bohemian Lodge Greenville, Autograph Collection

44 East Camperdown Way
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9.4
Excellent
428 Reviews

From

109$/night

The Lodge At Flat Rock

42 Mcmurray Road
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8.3
Very good
446 Reviews

From

114$/night

Comfort Inn & Suites Brevard North

2228 Asheville Hwy
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Luxury Hotels in Greenville City Centre

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8.5
Very good
195 Reviews

From

119$/night

Comfort Inn & Suites Greer - Greenville

1315 West Wade Hampton Blvd.
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8.5
Very good
240 Reviews

From

129$/night

Inn On The Square, An Ascend Collection Hotel

104 E. Court Avenue
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8
Very good
267 Reviews

From

86$/night

Comfort Suites Simpsonville - Greenville

3971 Grandview Drive
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7.8
Very good
157 Reviews

From

70$/night

Motel 6-Simpsonville, Sc - Greenville

3706 Grandview Drive
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9.4
Excellent
340 Reviews

From

344$/night

Hotel Hartness

120 Halston Avenue
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7.7
Very good
296 Reviews

From

89$/night

Country Inn & Suites By Radisson, Anderson, Sc

116 Interstate Boulevard
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8.9
Excellent
174 Reviews

From

201$/night

Outpost Inn

790 North 4Th Street
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9.2
Excellent
177 Reviews

From

281$/night

The Wells Cashiers

58 North Carolina 107
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9
Excellent
189 Reviews

From

217$/night

Ac Hotel By Marriott Spartanburg

225 West Main Street
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8.1
Very good
192 Reviews

From

121$/night

Comfort Suites Anderson-Clemson

118 Interstate Blvd
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7.8
Very good
167 Reviews

From

118$/night

Comfort Suites Piedmont - Greenville South

10 Kalyns Way
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7.4
Good
179 Reviews

From

112$/night

Comfort Inn & Suites Greenwood Near University

110 Birchtree Drive
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7.5
Very good
175 Reviews

From

101$/night

Comfort Suites Clinton Near Presbyterian College

12865 Hwy 56 North
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7.6
Very good
78 Reviews

From

85$/night

Rodeway Inn & Suites Walhalla

901 East Main Street
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7.1
Good
115 Reviews

From

70$/night

Quality Inn Forest City

205 Commercial Dr.
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Location

Greenville, South Carolina, United States, 29601

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